ACETONE / KETONE BODIES - URINE

Comment: Beta hydroxybutyrate, a predominant ketone is an extremely reliable guide for monitoring insulin therapy in the treatment of Diabetic Ketoacidosis (DKA). During successful therapy, Total ketones & Beta Hydroxybutyrate decreases but Acetoacetate increases. It may produce a paradoxical situation, as ketosis may appear to worsen because most of the tests for ketosis detects acetoacetate only whereas Beta hydroxybutyrate measurement quantitates this decrease. Its production increases during decreased carbohydrate availability as in starvation & frequent vomiting or decreased carbohydrate utilization as in Diabetes Mellitus, Glycogen storage diseases, Alkalosis & Salicylate poisoning.

Usage:  Monitoring therapy for Diabetic ketoacidosis · Investigating the differential diagnosis in cases of hypoglycemia, acidosis, suspected alcohol ingestion, or an unexplained increase in the anion gap · In pediatric patients, the presence or absence of ketonemia/uria is an essential component in the differential diagnosis of inborn errors of metabolism