ACYTYL COLINE RECEPTOR ANTIBODY

Notes:

Comments
Myasthenia gravis (MG) is characterized by weakness and easy fatigability that is relieved by rest and Anticholinesterase drugs. The weakness results from an autoantibody-mediated loss of functional acetylcholine receptors in the post-synaptic membrane of skeletal muscle. These antibodies are not found in congenital forms of MG and are uncommon in neurologic conditions other than Acquired MG. Patients with autoimmune liver disease may also be seropositive.

Clinical Uses 

Confirm the diagnosis of Myasthenia gravis · Distinguish acquired disease (90% positive) from Congenital disease (negative) · Detecting subclinical MG in patients with Thymoma or Graft versus Host disease · Monitoring disease progression in MG or response to Immunotherapy