ANTI BETA-2-GLYCOPROTEIN ANTIBODIES

NOTE:  This test screens for the presence of IgG antibodies to Beta-2 glycoprotein which are associated with arterial and venous thrombosis and recurrent abortions. The new International classification criteria for APS include Beta-2 glycoprotein for 2 key reasons namely: Ø Beta-2 Glycoprotein antibodies maybe the only antibody present in 10% patients of Antiphospholipid syndrome (APS) Beta-2 Glycoprotein antibodies are highly specific for APS unlike Anticardiolipin antibodies which may be positive in certain infectious diseases
Indications ·
Clinical history suggestive of Arterial or venous thrombosis · History of Recurrent fetal loss Intrauterine growth restriction/ Premature birth  ThrombocytopeniaNote:  This test screens for the presence of IgM antibodies to Beta-2 glycoprotein which are associated with arterial and venous thrombosis and recurrent abortions. The new International classification criteria for APS include Beta-2 glycoprotein for 2 key reasons namely: · Beta-2 Glycoprotein antibodies may be the only antibody present in 10% patients of Antiphospholipid syndrome (APS) · Beta-2 Glycoprotein antibodies are highly specific for APS unlike Anticardiolipin antibodies which may be positive in certain infectious diseasesIndications ·
Clinical history suggestive of Arterial or venous thrombosis
History of Recurrent fetal loss/Intrauterine growth restriction/Premature birth
Thrombocytopenia 
NOTE: Anti-Beta 2 Glycoprotein, IgA is associated with an increased risk of thromboembolic events, especially, among patients with SLE. Elevated Anti-Beta 2 glycoprotein, IgA may identify additional patients who have clinical features of Antiphospholipid syndrome(APS) but who do not meet current diagnostic criteria of APS.
Indications
Clinical history suggestive of Arterial or venous thrombosis
History of Recurrent fetal loss/intrauterine growth restriction/Premature birth
Thrombocytopenia