Calcitonin

Clinical Use

• Diagnose and monitor patients with Medullary thyroid carcinoma (MTC) which occurs as a sporadic disease or as a part of the syndromes of MEN-2A, MEN -2B & Familial MTC. Calcitonin is primarily used for diagnosing sporadic MTC/Index case in Familial MTC/monitoring MTC
• Routine screening of Nodular thyroid disease to detect unsuspected sporadic MTC
• For provocative testing in MTC, Calcitonin stimulation test is recommended to increase sensitivity of detection
• To monitor effectiveness of surgery by serial measurement of basal and stimulated calcitonin concentrations

Increased Levels

• Medullary carcinoma thyroid
• C-cell hyperplasia
• Non thyroidal cancers like Oat cell carcinoma / Small cell carcinoma, Intestinal / Bronchial / Gastric Carcinoids, Melanoma, Pheochromocytoma, Pancreatic carcinoma & Breast carcinoma
• Hypergastrinemia & other Gastrointestinal disorders
• Acute & Chronic Renal failure
• Hypercalcemia
• Pulmonary disease