FIBRINOGEN

Interpretation 

FIBRINOGEN, PLASMA-Conversion of Fibrinogen to Fibrin constitutes the final step in formation of clot. It is synthesized primarily in the liver. Quantitative or qualitative deficiency of Fibrinogen leads to poor clot formation and increased bleeding tendency. Fibrinogen is also an acute phase reactant. An increase in fibrinogen level is found in

1) Diabetes

2) Inflammatory conditions

3) Obesity

4) Malignancy

5) Use of oral contraceptives

6) Pregnancy

A decrease in fibrinogen level is observed in conditions associated with increased consumption and/or increased destruction of the protein (fibrinolysis) as listed below.

1) Disseminated Intravascular Coagulation

2) Increased fibrinolysis

3) Congenital hypo/afibrinogenemia

4) Decreased hepatic synthesis Fibrinogen seems to be involved in the pathogenesis of thrombo-cardio-vascular events