HLA B27 PCR QUALITATIVE
Why Is This Test Done?
Uses:
STRENGTH OF ASSOCIATION
Ankylosing spondylitis
++++
Reiter’s syndrome
++++
Reactive arthritis (Yersinia, Salmonella, Shigella &Chlamydia)+++Acute anterior uveitis
+++
Psoriatic spondylitis
+++
Notes:
• Certain inflammatory and non-inflammatory diseases are associated with the inheritance of HLA alleles .
• Ankylosing spondylitis and several postinfectious arthropathies are associated with the presence of HLA -B27.
• Individuals who inherit this class I allele have a 90 fold greater chance of developing the disease as compared to
those who do not carry HLA-B27.
• It is postulated that the mechanism underlying this association most probably influences T cell response.
• In cases of HLA-B27 negative Spondyloarthropathy, further testing recommended is HLA-C*06 (Positive in
Psoriatic arthritis) and HLA-B*07 (Positive in Juvenile and Undifferentiated Spondyloarthropathy).
Preparation Instructions
Mandatory Physician prescription, Molecular TRF
Procedure: A blood sample is drawn from a vein, usually in the arm.
Description:
The HLA-B27 PCR Qualitative test detects the presenc