What is the Quadruple Marker Test?
The Quadruple Marker Test, also known as the Quad Test, is a prenatal screening test that measures the levels of four specific substances in a pregnant woman's blood. It is primarily performed in the second trimester (between 15-20 weeks of pregnancy) to assess the risk of certain chromosomal abnormalities, such as Down syndrome (Trisomy 21), Trisomy 18, and neural tube defects like spina bifida.

The four substances measured in the test are:

1. Alpha-fetoprotein (AFP): A protein produced by the fetal liver.
2. Human chorionic gonadotropin (hCG): A hormone produced by the placenta.
3. Estriol (uE3): An estrogen produced by both the fetus and the placenta.
4. Inhibin A: A hormone produced by the placenta.

Purpose of the Quadruple Marker Test:

1. Assess Risk of Down Syndrome:

   • High hCG and Inhibin A, combined with low AFP and Estriol, may indicate an increased risk of Down syndrome.

2. Detect Trisomy 18:

   • Low levels of all four markers may suggest a risk of Trisomy 18, a more severe chromosomal abnormality.

3. Identify Neural Tube Defects:

   • Elevated levels of AFP could signal the presence of neural tube defects like spina bifida.

4. Screen for Fetal Development Issues:

   • The test does not provide a definitive diagnosis but rather helps identify pregnancies that may require further diagnostic testing.

Sample Type:
Blood sample (venipuncture).

Preparation for the Test:

• Fasting: No fasting is required for this test.
• Medications: Inform your healthcare provider about any medications or supplements you are taking.

Collection Method:

• A blood sample is drawn from a vein in your arm. The sample is then analyzed to measure the levels of the four markers.

Interpretation of Results:

• Results are typically provided as a risk ratio (e.g., 1 in 250). A higher risk ratio suggests a greater likelihood of the conditions being screened, but further diagnostic tests like amniocentesis or ultrasound may be needed for confirmation.

Graphical Interpretation of Quadruple Marker Test Results

A graphical representation of the Quadruple Marker Test shows how the levels of the four substances vary compared to typical levels in low-risk pregnancies. Here’s a breakdown of how these markers behave in different conditions:

1. Down Syndrome (Trisomy 21):

   • hCG: Increased
   • Inhibin A: Increased
   • AFP: Decreased
   • Estriol: Decreased

   Graph:

   • hCG and Inhibin A levels will be plotted above the normal range, while AFP and Estriol levels will be plotted below the normal range.

2. Trisomy 18:

   • All four markers (AFP, hCG, Estriol, Inhibin A) are typically decreased.

   Graph:

   • All markers will be plotted below the normal range, indicating a lower level of each substance.

3. Neural Tube Defects (Spina Bifida):

   • AFP: Increased
   • Other markers (hCG, Estriol, Inhibin A) remain within the normal range.

   Graph:

   • AFP will be plotted above the normal range, while other markers will stay at normal levels.

SpeedDiagno Booking and Collection:

• Book Easily: Schedule your Quadruple Marker Test through the SpeedDiagno app or website.
• Fast Sample Collection: SpeedDiagno offers rapid sample collection, often within minutes of booking, depending on your location and technician availability.
• At-Home Service: A trained phlebotomist can collect your blood sample at your home or office.

Turnaround Time:

• Sample Collection: The blood draw takes just a few minutes.
• Results: Typically available within 3-5 days, and results can be accessed directly via the SpeedDiagno app or website.

Why Choose SpeedDiagno?

• Instant Booking: Schedule your Quadruple Marker Test easily through the SpeedDiagno app or website.
• Fast Service: Rapid sample collection and timely results.
• Convenience: Enjoy at-home collection and easy access to your results online.
• Accurate Testing: We partner with NABL certified labs to ensure the highest level of testing accuracy.

Consultation:

• After receiving your results, consult your healthcare provider to understand your risk levels and discuss any further testing or monitoring that may be necessary.

Support:
For any additional information or queries, contact our customer support team.